Liverpool have drawn holders Real Madrid in the last 16 of the Champions League in a repeat of last season's final.
Fourteen-time winners Real Madrid beat Liverpool 1-0 in last year's final in Paris thanks to a goal from Vinicius Junior in the 59th minute.
Premier League champions Manchester City face German side RB Leipzig, while Tottenham play Italian giants AC Milan.
Chelsea also have German opposition in Borussia Dortmund.
Elsewhere, French champions Paris St-Germain have drawn Bayern Munich.
The last-16 first legs will take place on 14-15 and 21-22 February, with the second legs on 7-8 and 14-15 March.
Full last-16 draw:
RB Leipzig v Manchester City
Club Bruges v Benfica
Liverpool v Real Madrid
AC Milan v Tottenham
Frankfurt v Napoli
Borussia Dortmund v Chelsea
Inter Milan v Porto
Paris St-Germain v Bayern Munich